Kickoff from U.S. Bank Stadium in Minneapolis is set for 4:30 p.m. ET. The latest Vikings vs. Lions odds have Detroit favored by 7 points, while the over/under for total points scored is 44.5 via DraftKings Sportsbook. Before making any Lions vs. Vikings picks, check out the NFL predictions from the SportsLine Projection Model .

Week 17’s schedule starts with a three-game slate on Christmas. We predict the winners for each of those three games and give you a chance to join in.

It’s Christmas Day, and this is the last of three games on the NFL slate. The AFC-leading Broncos head to Kansas City to face the defeated and injury-riddled Chiefs. The Broncos will look to inch closer to locking down the number one seed in the conference,

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.