George Kittle’s injured ankle forced him to miss practice again on Thursday, leaving the 49ers’ Pro Bowl tight end’s status for Sunday night’s game against the Chicago Bears in question.

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

Here are your top 49ers storylines for Wednesday, December 24th:

The San Francisco 49ers beat the Indianapolis Colts 48-27, led by Brock Purdy’s 5 TDs. Colin Cowherd asks if the now 11-4 49ers are serious title contenders.

Need to know. Brock off a bye. 49ers quarterback Brock Purdy has played two games off a bye in his career, and he has been nearly perfect in both. In those two g

QB Brock Purdy rewards his offensive line with custom Rolex watches for Christmas as San Francisco pushes toward the NFC West title and NFL playoffs.

The San Francisco 49ers continue mostly trending the right way on the injury front as they head into a Week 17 matchup with the Chicago Bears.

San Francisco (11-4) finishes the season with games at home against Chicago and Seattle. With wins in both of those, the 49ers would clinch home-field advantage in the NFC playoffs and would be two wins away from playing in the Super Bowl in their home stadium on Feb. 8.