DCs loaded with tumor antigens have been shown to inhibit tumor growth in several mouse models. 6,7 Methods used to load tumor antigen in these studies include pulsing DCs with defined peptide ...
The elaboration of an efficient immune response against pathogens involves complex intracellular antigen-processing events. Endogenous antigens such as viral proteins synthesized by infected host ...
To better understand the generation of MHC class l-associated peptides, we used a model antigenic protein whose proteasomemediated degradation is rapidly and reversibly controlled by Shield-1, a ...
EMERYVILLE, Calif., Feb. 27, 2019 (GLOBE NEWSWIRE) -- Gritstone Oncology, Inc. (Nasdaq:GRTS), a clinical-stage biotechnology company developing the next generation of cancer immunotherapies to fight ...
The major histocompatibility complex (MHC) is a group of genes that encode proteins on the cell surface that have an important role in immune response. Their main role is in antigen presentation where ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 9 (Feb. 28, 2006), pp. 3327-3332 (6 pages) We explored the role of antigen valency in B cell receptor ...
Background: We have shown that the high prevalence of HLA-A2 in Scandinavia is associated to poor prognosis in advanced (stage III-IV) serous adenocarcinoma of the ovary. Our objective was to analyse ...
Cabozantinib As Salvage Therapy for Patients With Tyrosine Kinase Inhibitor–Refractory Differentiated Thyroid Cancer: Results of a Multicenter Phase II International Thyroid Oncology Group Trial ...
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