Watch the best plays from San Francisco 49ers running back Christian McCaffery's 146-yard game against the Indianapolis Colts in Week 16 of the 2025 NFL season.

The last of the ABC22/FOX44 Top Plays of the Year semifinal nominees are here VOTE HERE Ken Drake will have the results coming up on Friday 12/26

Ranking the NFL’s top 10 quarterbacks heading into Week 17, breaking down elite play, recent trends, MVP cases, and which stars are carrying their teams.

Watch the top defensive plays from Week 16 of the 2025 NFL season. Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

The lone active player on our list, Chiefs quarterback Patrick Mahomes has already cemented himself as one of the top 30 players in NFL history, despite having only nine years of professional experience.