Prophylactic HPV vaccines prevent infection but not existing disease. A nasal nanogel vaccine shows preclinical promise for ...

Therapeutic cancer vaccines have experienced a remarkable resurgence over the past decade, representing a paradigm shift in oncology toward harnessing the immune system's intrinsic ability to combat ...

Trained immunity is reshaping our understanding of host defense by demonstrating that innate immune cells once thought to lack memory can be reprogrammed to mount heightened responses to subsequent ...

When a transplanted organ arrives, it’s like a controlled burn that risks becoming a wildfire. The body’s innate immune system senses damage signals, like heat shock proteins (HSP70), and sounds the ...

The field of cancer research has increasingly focused on the intricate interplay between regulated cell death (RCD) pathways and the immune microenvironment in tumor progression and treatment.

RIDE-001 was developed using Trained Therapeutix’s proprietary ApoA1-based nanomedicines platform to target the bone marrow where it activates the intracellular pattern recognition receptor NOD2. This ...

The articles in this focus issue discuss progress towards a more complete understanding of memory in the innate immune system, and efforts to exploit "trained immunity" for the development of new ...

Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells.

Myeloid cells constitute essential components within the immunosuppressive microenvironment of various tumors, significantly influencing cancer progression and resistance to therapeutic interventions.