Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 41 (October 9, 2018), pp. 10493-10498 (6 pages) Dopaminergic signaling in the striatum, particularly at ...

A phase 1b/2 study of the combination of the IDO pathway inhibitor indoximod and temozolomide for adult patients with temozolomide-refractory primary malignant brain tumors: Safety analysis and ...

Proteins are molecular machines that carry out most of the work performed by the cells in the body, but when proteins fail at doing their job disease usually follows. To perform their functions, ...

Dopamine, a chemical that sends messages between different parts of the brain and body, plays a key role in a variety of diseases and behaviors by interacting with receptors on cells. But despite ...

It’s no surprise that many of the highly processed foods we consume pack just as much of a dopamine punch as alcohol, drugs, sex, and rock n’ roll. As restaurants and food-product businesses compete ...

The arousing and motor-activating effects of psychostimulants are mediated by multiple systems. In Drosophila, dopaminergic transmission is involved in mediating the arousing effects of ...

Research has shown that dopamine (DA) plays a key role in how the body regulates the production of insulin. Typically, insulin is secreted by beta-cells in the pancreas in response to glucose—a ...

Only 30% of patients who start GLP-1s for weight loss are still using them after one year, with GI side effects cited as the #1 cause of treatment discontinuation NG101 is a first-in-class therapy ...