Pittsburgh scored four touchdowns in the second half to pull away from the Dolphins, who came into the game having won four in a row and five of their last six after starting the season 1-6. For the Steelers, the win keeps them in first place in the AFC North Division, one game ahead of the Baltimore Ravens.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle totaled seven receptions for 115 yards and a TD before leaving the game with an ankle injury.

Minnesota Vikings quarterback J.J. McCarthy threw for 250 yards and 2 touchdowns with 1 interception in win against the Dallas Cowboys.

ESPN's "Monday Night Football" matchup will have a major impact on both the AFC and NFC playoff pictures. Here's what to know about the Week 16 game.