The interrupted non-coding regions in pre-mRNAs, termed “introns,” are excised by “splicing” to generate mature coding mRNAs that are translated into proteins. As human pre-mRNA introns vary in length ...

University of California (UC), San Diego, biochemists studying the evolutionary origins and history of RNA splicing and the human genome combined two-dimensional (2D) images of individual molecules to ...

The Plant Cell is in its 19th year of publication. Within three years of its initial publication, it ranked first in impact among primary research journals in the plant sciences, a standard of ...

Previous studies have suggested that differences in the ability of normal and malignant cells to process certain alternatively spliced pre-mRNA transcripts can be exploited as a potentially powerful ...

Diet determines the placement of methylation signatures like post-its at specific sites on a messenger RNA (mRNA) marking the molecules for degradation, a new study on the microscopic model worm, ...

The movie provides a direct view of the splicing mechanism catalyzed by the group II intron ribozymes. Magnified view of the ribozyme active site. The exon is shown in blue, the intron in green, Mg2+ ...

Although you may not appreciate them, or have even heard of them, throughout your body, countless microscopic machines called spliceosomes are hard at work. As you sit and read, they are faithfully ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor Protein-coding genes carry the blueprint for protein production. In higher ...