ESPN's "Monday Night Football" matchup will have a major impact on both the AFC and NFC playoff pictures. Here's what to know about the Week 16 game.

San Francisco aims to improve playoff position while Indianapolis fights for postseason hopes with Philip Rivers at quarterback. Here's how to watch for free.

Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how to watch live and streaming.

With a mini-bye week following their loss to the Seattle Seahawks last Thursday night, the Los Angeles Rams move forward with another primetime matchup, this ti

Daily Fantasy multimillionaire Mike McClure reveals his daily Fantasy football picks for Indianapolis vs. San Francisco on 'MNF'

Phillip Rivers leads the Indianapolis Colts against Brock Purdy and the San Francisco 49ers tonight in this NFL Week 16 showdown.

Joe Montana was the last 49ers quarterback to throw five touchdowns when he did it in 1990.The 49ers improved to 11-4 with a fifth consecutive win. The Colts fell to 8-7, with their loss clinching playoff berths for the Bills,

Now, the model has analyzed Colts vs. 49ers on 'Monday Night Football' and locked in three confident best bets for an NFL SGP. If you successfully parlay its picks, you'd be looking at a payout of well over 6-1. You can only see the Machine Learning Model player prop predictions for San Francisco vs. Indianapolis here.

Now back as the wily super-veteran, Rivers is pulling out all the tricks. And on this one, it worked to give the Colts an early lead. Indy's defense couldn't stop the 49ers all night, which spoiled a good game from Rivers. But the 44-year old proved he can still get it done, and it was pretty darn fun to watch.