Week 17 of the 2025 NFL season kicks off with a triple-header of division rivalries on Christmas Day and wraps up Monday with the Los Angeles Rams visiting the Atlanta Falcons.

Some of the site's predictions differ from NFL Week 17 odds and other NFL Week 17 picks for NFL Week 17 games. How correct will the analytics be this week? Click on each game for more NFL Week 17 predictions for that NFL matchup. All times MST. The site allows for the possibility of ties, so the numbers add up to just less than 100%.

On the Eagles' end, their weakness has been turnovers. Philadelphia has four games this year with two or more turnovers and the Eagles have gone 0-4 in those games. If any defense out there can take advantage of that, it's a Bills unit that has forced 20 turnovers this year, which ranks in the top eight in the NFL.

NFL Week 17 predictions, picks for games this week, including Broncos-Chiefs, Eagles-Bills, Bears-49ers, Rams-Falcons, Ravens-Packers, Giants-Raiders.

Happy holidays—and a Merry Christmas—to all who celebrate. The NFL invites you to start your celebration with some NFL action today.

For Week 17 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 17 NFL schedule here. After analyzing every game in Week 17, the AI says the Steelers (-3, 33.5), who have won three in a row, cover comfortably against the Browns.

USA Today's NFL experts make their picks for a Week 17 showdown between the Tennessee Titans and New Orleans Saints

Two of the hottest teams in the NFL meet Saturday afternoon in Southern California when C.J. Stroud and the Houston Texans (10-5) take on Justin Herbert and the Los Angeles Chargers (11-4) at SoFi Stadium. The Texans have won seven straight and the Chargers four in a row and seven of their last eight.