On defense, the 49ers enter Week 17 averaging 21.3 points per game (11th in the NFL), while the Bears are 19th at 23.6 points per game. The 49ers have the superior run defense; they rank 8th in the NFL in rushing yards allowed per game, whereas the Bears are 27th.

On the Eagles' end, their weakness has been turnovers. Philadelphia has four games this year with two or more turnovers and the Eagles have gone 0-4 in those games. If any defense out there can take advantage of that, it's a Bills unit that has forced 20 turnovers this year, which ranks in the top eight in the NFL.

Some of the site's predictions differ from NFL Week 17 odds and other NFL Week 17 picks for NFL Week 17 games. How correct will the analytics be this week? Click on each game for more NFL Week 17 predictions for that NFL matchup. All times MST. The site allows for the possibility of ties, so the numbers add up to just less than 100%.

In addition to the rankings, we asked our NFL Nation reporters to pick the rookie of the year for each team. From top quarterbacks to dynamic defenders, which first-year players stood out from the rest?

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 on a 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Happy holidays—and a Merry Christmas—to all who celebrate. The NFL invites you to start your celebration with some NFL action today.

The Detroit Lions face the Minnesota Vikings on Christmas Day. Kickoff from Minneapolis, Minnesota, is set for 4:30 p.m. ET.

It’s Christmas Day, and this is the second of three games on the NFL slate. The Detroit Lions head to Minnesota to take on their division rivals, the Vikings, in what is expected to be a low-scoring game.