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This is a big game in terms of playoff push, but both teams have locked up playoff berths. The Eagles are playing for seeding, while the Bills are just hoping to win two and hope the Pats lose to have a chance to win the division. This could be a game that gets a little loose, with the Bills winning it late with a field goal in the final seconds.
Week 17 is also loaded with playoff implications. Teams like the Houston Texans (10-5), Los Angeles Chargers (11-4), Chicago Bears (11-4) and San Francisco 49ers (11-4) are still vying for higher seeds in the AFC and NFC.
Each pick has a confidence level of 1-10, with 10 being the most confident. For more information on the pick methodology, check out the Week 1 edition of this series. Keep in mind that since the idea here is to make high-percentage plays,
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Lions vs. Vikings prediction, odds, start time: 2025 Christmas Day NFL picks from proven model
Kickoff from U.S. Bank Stadium in Minneapolis is set for 4:30 p.m. ET. The latest Vikings vs. Lions odds have Detroit favored by 7.5 points, while the over/under for total points scored is 43.5 via DraftKings Sportsbook. Before making any Lions vs. Vikings picks, check out the NFL predictions from the SportsLine Projection Model .
NFL picks, predictions for Week 17: Packers clinch playoff spot against Ravens, Chargers edge Texans
In Sporting News' Week 17 picks and predictions, Lions get a season-saving win while Broncos right the ship against a division foe.
The Detroit Lions (8-7) have zero players listed on their injury report as they ready to play the Minnesota Vikings (7-8) on Thursday, Dec. 25 at U.S. Bank Stadium, with the opening kick scheduled for 4:30 p.
The Denver Broncos and Kansas City Chiefs clash Christmas night. Kickoff for Thursday Night Football is at 8:15 p.m. ET in Kansas City, Missouri.
These teams met earlier this season on November 2 with the Vikings prevailing 27-24. McCarthy threw a couple of touchdown passes and the Vikings outgained the Lions on the ground, 142-65 to earn the win.