Outcomes in patients with pancreatic and ampullary cancer whose tumors harbor pathogenic APC mutations. Utility of circulating tumor DNA (ctDNA) for the detection of minimal residual disease (MRD) ...
In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across ...
Targets primarily include PCSK9, ANGPTL3, HSD17B13, KHK, ASGR1, GPR75, CIDEB, and INHBE. Drug types primarily include small molecules, monoclonal antibodies, RNAi, and CRISPR gene editing therapies.
The system of long noncoding RNA (lncRNA)–mediated transcriptional interference that represses fission yeast phosphate homoeostasis gene pho1 provides a sensitive readout of genetic influences on ...
A new research paper was published in Volume 16 of Genes & Cancer on January 20, 2025, entitled, "Analysis of pathogenic variants in retinoblastoma reveals a potential gain of function mutation." ...
4don MSN
Aquaporin gene duplication followed by mutation in European eels restores broad solute permeability
Common ancestor eels lost the aquaporin gene encoding proteins with broad solute permeability. Researchers from the Institute ...
SCLC has a poor prognosis with less than 7% 5-year survival, and limited surgical specimens hinder understanding. FAK inhibition is identified as a potential therapeutic target due to high-frequency ...
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