San Francisco aims to improve playoff position while Indianapolis fights for postseason hopes with Philip Rivers at quarterback. Here's how to watch for free.

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on Dec. 22. Who will win?

Here’s what you need to know about Monday Night Football.

The San Francisco 49ers, on a four-game winning streak, try to stay hot Monday night against an Indianapolis Colts team on a four-game losing streak.

Daily Fantasy multimillionaire Mike McClure reveals his daily Fantasy football picks for Indianapolis vs. San Francisco on 'MNF'

Jauan Jennings reeled in a sweet touchdown catch from Brock Purdy on Monday night, and then the San Francisco 49ers ' WR ran toward the stands. It looked like he was considering handing the TD football to a fan, but when he got there on the road, all he saw was a group of Indianapolis Colts fans.

RALEIGH — For two weeks in December, the NC State community was captivated by one of its favorite former quarterbacks, shocking the NFL world. Philip Rivers, now 44, came out of a five-year retirement to try to help the Indianapolis Colts save their season after losing starting quarterback Daniel Jones for the season.

Now, the model has analyzed Colts vs. 49ers on 'Monday Night Football' and locked in three confident best bets for an NFL SGP. If you successfully parlay its picks, you'd be looking at a payout of well over 6-1. You can only see the Machine Learning Model player prop predictions for San Francisco vs. Indianapolis here.

The Jacksonville Jaguars clinched their playoff spot during Monday Night Football when the Indianapolis Colts lost to the San Francisco 49ers. Jaguars players and fans were surely be tuned in to watch their division rival and see if they can punch their postseason pass.