Abstract: Glycosylation of proteins in eukaryote cells is an important and complicated post-translation modification due to its pivotal role and association with crucial physiological functions within ...

Depression is a debilitating mental health disorder that remains a substantial global health challenge. Despite the availability of various antidepressants, treatment outcomes often face limited ...

Aberrant Glycosylation Drives Kidney Disease Pathogenesis. This schematic illustrates how abnormal glycosylation contributes to diverse kidney diseases: (A) galactose-deficient IgA1 in ...

This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2020. Mammalian cells contain only one glycosyltransferase, OGT, that ...

Protein glycosylation, particularly O-GlcNAcylation, is a critical post-translational modification (PTM) that regulates cardiac and vascular functions by modulating protein stability, localization, ...

Protein glycosylation is a complex post-translational modification that is generally classified as N- or O-linked. Site-specific analysis of glycopeptides is accomplished with a variety of ...

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Ebola virus (EBOV) is a hemorrhagic virus endemic to Africa, which can spread rapidly in populated areas and has a high rate of fatality. Significant media attention was garnered during outbreaks over ...

Background: Aberrant O-glycosylation of IgA1 plays an important role in IgA nephropathy pathogenesis. Previous proteomic studies analyzed O-glycans of the circulating IgA1 hinge region and found that ...

The Chinese hamster ovary (CHO) cell line was first established by Theodore Puck in the 1950s and was used mainly for cytogenetics studies (1). Since the 1990s, CHO cells have increased in popularity ...